Both schizophrenia and bipolar disorder contribute significantly to this burden of disease, with schizophrenia being the fifth leading cause of years lost due to disability among men, and the sixth among women, while bipolar disorder is in the seventh and eighth position, respectively¹.

Major depressive disorder is a chronic, particularly widespread condition resulting in disability. Despite the large number of approved treatments, response rates with initiation treatments are estimated to be approximately 50%, with remission rates ranging from 30% to 40%².

The characteristic symptom of generalized anxiety disorder is anxiety, which is generalized and persistent, without necessarily being due to a particular event or situation. As with other anxiety disorders, the dominant symptoms may vary; however, symptoms such as constant feeling of nervousness, tremor, muscle tension, sweating, dizziness, palpitations and epigastric discomfort are common. Also, fears are often expressed that the patient or a close person will soon become ill or will have an accident, and these are usually accompanied by other additional concerns and prejudices. This disorder is more common in women and is often associated with chronic environmental stress. Its course may vary, but it often fluctuates and is chronic³.

Epilepsy is the chronic condition where recurrent episodes of epileptic seizures occur due to existing brain impairment. It may appear across the entire age range, from infants to the elderly, and has various causes and manifestations, with many different types of seizures, several recognizable syndromes, but also many others that are inadequately classified. There are many co-morbidities that can complicate the diagnosis and treatment, including learning difficulties, neurological deficits and other developmental conditions, psychological and psychiatric problems, and especially in older age, coexisting conditions⁴.

Neuropathic pain is defined as the pain caused by either a peripheral (peripheral neuropathic pain) or central (central neuropathic pain) somatosensory nervous system impairment or disease⁵.he incidence of neuropathic pain in the general population is 5%⁶. Neuropathic pain is a clinical symptom rather than a diagnosis, requiring the presence of a clear lesion or disease that meets established neurological diagnostic criteria. The term “lesion” is used either when diagnostic laboratory tests confirm clearly the presence of a malfunction or when there is an obvious injury. The term “disease” is used when the etiology of the lesion is known (e.g. stroke, diabetes mellitus, etc.)⁷.